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Mayfly is a highly carcinogenic alien-derived transformative bioagent.

When injected into a human, Mayfly continuously generates exotic tumors in the brain, resulting in death within 24 hours. However, in 1 out of 500 humans, the alien cancer cells turn them into supragenius-level savants for the short time until they die. Typical Mayfly users are people who are desperate and/or already dying.

According to Weirdbeard, the few doses of Mayfly kept at the Purple Paladin Memorial Hospital are worth $100,000 on the black market.

The aspiring supervillain Manny used Mayfly.